Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions.

ABSTRACT: The versatility of cellular response arises from the communication, or crosstalk, of signaling pathways in a complex network of signaling and transcriptional regulatory interactions. Understanding the various mechanisms underlying crosstalk on a global scale requires untargeted computational approaches. We present a network-based statistical approach, MuXTalk, that uses high-dimensional edges called multilinks to model the unique ways in which signaling and regulatory interactions can interface. We demonstrate that the signaling-regulatory interface is located primarily in the intermediary region between signaling pathways where crosstalk occurs, and that multilinks can differentiate between distinct signaling-transcriptional mechanisms. Using statistically over-represented multilinks as p

SUBMITTER: Martini L 

PROVIDER: S-EPMC10783515 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature