Timolol maleate, a β blocker eye drop, improved edema in a retinal vein occlusion model.

ABSTRACT:

Purpose

To investigate the therapeutic effects of eye drops, namely, timolol maleate, a β-adrenergic receptor antagonist, and latanoprost, a prostaglandin F2α analog, on retinal edema in a murine retinal vein occlusion (RVO) model.

Methods

An RVO model was established using laser-induced RVO in mice, which were administered timolol maleate and latanoprost eye drops several times after venous occlusion. Subsequently, the thickness of the inner nuclear layer (INL) and the expression levels of such genes as Vegf and Atf4, which are stress markers of the endoplasmic reticulum, were examined. Primary human cultured retinal microvascular endothelial cells (HRMECs) were treated with timolol under hypoxic conditions, after which the gene expression pattern was investig

SUBMITTER: Fuma S 

PROVIDER: S-EPMC10784217 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature