Large-scale effective connectivity analysis reveals the existence of two mutual inhibitory systems in patients with major depression.

ABSTRACT: It is posited that cognitive and affective dysfunction in patients with major depression disorder (MDD) may be caused by dysfunctional signal propagation in the brain. By leveraging dynamic causal modeling, we investigated large-scale directed signal propagation (effective connectivity) among distributed large-scale brain networks with 43 MDD patients and 56 healthy controls. The results revealed the existence of two mutual inhibitory systems: the anterior default mode network, auditory network, sensorimotor network, salience network and visual networks formed an "emotional" brain, while the posterior default mode network, central executive networks, cerebellum and dorsal attention network formed a "rational brain". These two networks exhibited excitatory intra-system connectivity and inhi

SUBMITTER: Wang J 

PROVIDER: S-EPMC10784315 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature