The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms.

ABSTRACT: Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation for the emergence of Gompertzian mortality patterns using a systems approach to describe aging in complex organisms that consist of many inter-dependent subsystems. Our model relates to the Sufficient-Component Cause Model, widely used within the field of epidemiology, and we show that including inter-dependencies between subsystems and modeling the temporal evolution of subsystem failure results in Gompertizan mortality on the population level. Our model also provides temporal trajectories of mortality-ri

SUBMITTER: Nielsen PY 

PROVIDER: S-EPMC10786855 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature