Characteristics of gut microbiota in patients with asthenozoospermia: a Chinese pilot study.

ABSTRACT:

Background

Identification of intestinal flora composition is significant for exploring the cause and pathogenic mechanisms of the gut-testis axis and clarifying the relationship between microbiota and infertility. Our study aimed to examine the alternation in gut microbiota composition and identify potential microbes associated with development of Asthenozoospermia (AS).

Method

A total of 580 males were recruited in the outpatient department of Tianjin Medical University General Hospital between September 2021 and March 2023. Sperm parameters were analyzed according to the WHO laboratory manual. The 16 S rRNA gene high-throughput sequencing was performed to detect the gut microbiota composition in fecal samples. LEfSe analysis was used to screen key microbiota. PICRUSt2 soft

SUBMITTER: Pan Y 

PROVIDER: S-EPMC10789020 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature