Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: Ukraintseva S
PROVIDER: S-EPMC10789330 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Publications
Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.
Ukraintseva Svetlana S Duan Hongzhe H Holmes Rachel R Bagley Olivia O Wu Deqing D Yashkin Arseniy A Kulminski Alexander A Akushevich Igor I Whitson Heather H Stallard Eric E Yashin Anatoliy A Arbeev Konstantin K
Journal of Alzheimer's disease : JAD 20240101 1
Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax ...[more]
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