Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

ABSTRACT: Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.

SUBMITTER: Ukraintseva S 

PROVIDER: S-EPMC10789330 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature