Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4⁺ T cells.

ABSTRACT: Following an oral inoculation, Chlamydia muridarum descends to the mouse large intestine for long-lasting colonization. However, a mutant C. muridarum that lacks the plasmid-encoded protein pGP3 due to an engineered premature stop codon (designated as CMpGP3S) failed to do so even following an intrajejunal inoculation. This was because a CD4⁺ T cell-dependent immunity prevented the spread of CMpGP3S from the small intestine to the large intestine. In the current study, we found that mice deficient in IL-22 (IL-22^-/-) allowed CMpGP3S to spread from the small intestine to the large intestine on day 3 after intrajejunal inoculation, indicating a critical role of IL-22 in regulating the chlamydial spread. The responsible IL-22 is produced by CD4⁺

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10790816 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature