Dataset Information

QRS fragmentation does not predict mortality in survivors of acute myocardial infarction.

ABSTRACT:

Background

Despite advances in coronary revascularization and in heart failure management, myocardial infarction survivors remain at substantially increased mortality risk. Precise risk assessment and risk-adapted follow-up care are crucial to improve their outcomes. Recently, the fragmented QRS complex, i.e. the presence of additional spikes within the QRS complexes on a 12-lead electrocardiogram, has been discussed as a potential non-invasive risk predictor in cardiac patients.

Hypothesis

The aim of this study was to evaluate the prognostic meaning of the fragmented QRS complex in myocardial infarction survivors.

Methods

609 patients with narrow QRS complexes <120 ms were included in a prospective cohort study while hospitalized for myocardial infarction and followed for 5 years.

Results

The prevalence of the fragmented QRS complex in these patients amounted to 46.8% (285 patients). These patients had no increased hazard of all-cause death (HR 0.84, 95%-CI 0.45-1.57, p = 0.582) with a mortality rate of 6.0% compared to 7.1% in patients without QRS fragmentations. Furthermore, the risks of cardiac death (HR 1.28, 95%-CI 0.49-3.31, p = 0.613) and of non-cardiac death (HR 0.6, 95%-CI 0.26-1.43, p = 0.25) were not significantly different in patients with QRS fragmentations. However, patients with QRS fragmentations had increased serum creatine kinase concentrations (1438U/l vs. 1160U/l, p = 0.039) and reduced left ventricular ejection fractions (52% vs. 54%, p = 0.011).

Conclusions

The hypothesis that QRS fragmentation might be a prognostic parameter in survivors of myocardial infarction was not confirmed. But those with QRS fragmentation had larger myocardial infarctions, as measured by creatine kinase and left ventricular ejection fraction.

SUBMITTER: Allescher J

PROVIDER: S-EPMC10797824 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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QRS fragmentation does not predict mortality in survivors of acute myocardial infarction.

Allescher Julia J Sinnecker Daniel D von Goeldel Bernhard B Barthel Petra P Müller Alexander A Hapfelmeier Alexander A Martens Eimo E Laugwitz Karl-Ludwig KL Schmidt Georg G Steger Alexander A

Clinical cardiology 20240101 1

<h4>Background</h4>Despite advances in coronary revascularization and in heart failure management, myocardial infarction survivors remain at substantially increased mortality risk. Precise risk assessment and risk-adapted follow-up care are crucial to improve their outcomes. Recently, the fragmented QRS complex, i.e. the presence of additional spikes within the QRS complexes on a 12-lead electrocardiogram, has been discussed as a potential non-invasive risk predictor in cardiac patients.<h4>Hypo ...[more]

PMID: 38269630

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Dataset Information

QRS fragmentation does not predict mortality in survivors of acute myocardial infarction.

Background

Hypothesis

Methods

Results

Conclusions

Publications

QRS fragmentation does not predict mortality in survivors of acute myocardial infarction.

Similar Datasets

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