Unknown

Dataset Information

0

Insulin-like growth factor 1 associated with altered immune responses in preterm infants and pigs.


ABSTRACT:

Background

Preterm infants show low blood levels of insulin-like growth factor 1 (IGF-1), known to be negatively correlated with Interleukin-6 (IL-6). We hypothesized that circulating IGF-1 is associated with systemic immune-markers following preterm birth and that exogenous IGF-1 supplementation modulates immune development in preterm pigs, used as model for preterm infants.

Methods

Plasma levels of IGF-1 and 29 inflammatory markers were measured in very preterm infants (n = 221). In preterm pigs, systemic immune development, assessed by in vitro challenge, was compared between IGF-1 treated (2.25 mg/kg/day) and control animals.

Results

Preterm infants with lowest gestational age and birth weight showed the lowest IGF-1 levels, which were correlated not only with IL-6, but a range of immune-markers. IGF-1 supplementation to preterm pigs reduced plasma IL-10 and Interferon-γ (IFN-γ), IL-2 responses to challenge and reduced expression of genes related to Th1 polarization. In vitro addition of IGF-1 (100 ng/mL) further reduced the IL-2 and IFN-γ responses but increased IL-10 response.

Conclusions

In preterm infants, plasma IGF-1 correlated with several immune markers, while supplementing IGF-1 to preterm pigs tended to reduce Th1 immune responses. Future studies should document whether IGF-1 supplementation to preterm infants affects immune development and sensitivity to infection.

Impact

Supplementation of insulin-like growth factor 1 (IGF-1) to preterm infants has been proposed to promote postnatal growth, but its impact on the developing immune system is largely unknown. In a cohort of very preterm infants, low gestational age and birth weight were the primary predictors of low plasma levels of IGF-1, which in turn were associated with plasma immune markers. Meanwhile, in immature preterm pigs, experimental supplementation of IGF-1 reduced Th1-related immune responses in early life. Supplementation of IGF-1 to preterm infants may affect the developing immune system, which needs consideration when evaluating overall impact on neonatal health.

SUBMITTER: Bæk O 

PROVIDER: S-EPMC10798898 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Insulin-like growth factor 1 associated with altered immune responses in preterm infants and pigs.

Bæk Ole O   Rasmussen Martin Bo MB   Gerts Therese T   Aunsholt Lise L   Zachariassen Gitte G   Sangild Per P   Nguyen Duc Ninh DN  

Pediatric research 20230830 1


<h4>Background</h4>Preterm infants show low blood levels of insulin-like growth factor 1 (IGF-1), known to be negatively correlated with Interleukin-6 (IL-6). We hypothesized that circulating IGF-1 is associated with systemic immune-markers following preterm birth and that exogenous IGF-1 supplementation modulates immune development in preterm pigs, used as model for preterm infants.<h4>Methods</h4>Plasma levels of IGF-1 and 29 inflammatory markers were measured in very preterm infants (n = 221)  ...[more]

Similar Datasets

| S-EPMC10112548 | biostudies-literature
| S-EPMC7891102 | biostudies-literature
| S-EPMC9389362 | biostudies-literature
| S-EPMC10315495 | biostudies-literature
| S-EPMC11555815 | biostudies-literature
| S-EPMC5156408 | biostudies-literature
| S-EPMC11494451 | biostudies-literature
| S-EPMC3582631 | biostudies-literature
| S-EPMC8058368 | biostudies-literature
| S-EPMC5994241 | biostudies-literature