Effect of adjuvant chemotherapy on the oncological outcome of rectal cancer patients with pathological complete response.

ABSTRACT:

Background

Locally advanced rectal cancer is typically treated using a combination of neoadjuvant chemoradiotherapy and total mesorectal resection. While achieving pathological complete response following neoadjuvant chemoradiotherapy has been recognized as a positive prognostic factor in oncology, the necessity of adjuvant chemotherapy for locally advanced rectal cancer patients with pathological complete response after surgery remains uncertain. The objective of this meta-analysis was to examine the impact of adjuvant chemotherapy on the oncological outcomes of rectal cancer patients who attain pathological complete response after neoadjuvant chemoradiotherapy.

Methods

This meta-analysis followed the guidelines outlined in the preferred reporting items for systematic revie

SUBMITTER: Yang J 

PROVIDER: S-EPMC10809453 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature