A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues.

ABSTRACT: Drug-eluting stent implantation suppresses the excessive proliferation of smooth muscle cells to reduce in-stent restenosis. However, the efficacy of drug-eluting stents remains limited due to delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here, we show that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response to injured tissue following stent implantation. We demonstrate that the one-produces-multi coating possesses anticoagulation, anti-inflammatory, and intimal hyperplasia suppression properties. We perform transcriptome analysis to indicate that the drug-free coating favors the endothelialization process and induces the conversion of smoot

SUBMITTER: Wu H 

PROVIDER: S-EPMC10810808 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature