Bioinformatic Discovery of a Cambialistic Monooxygenase.
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ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC10811679 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Bioinformatic Discovery of a Cambialistic Monooxygenase.
Liu Chang C Powell Magan M MM Rao Guodong G Britt R David RD Rittle Jonathan J
Journal of the American Chemical Society 20240110 3
Dinuclear monooxygenases mediate challenging C-H bond oxidation reactions throughout nature. Many of these enzymes are presumed to exclusively utilize diiron cofactors. Herein we report the bioinformatic discovery of an orphan dinuclear monooxygenase that preferentially utilizes a heterobimetallic manganese-iron (Mn/Fe) cofactor to mediate an O<sub>2</sub>-dependent C-H bond hydroxylation reaction. Unlike the structurally similar Mn/Fe-dependent monooxygenase AibH2, the diiron form of this enzym ...[more]
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