Single-cell transcriptome analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer.

ABSTRACT: A comprehensive investigation of ovarian cancer (OC) progression at the single-cell level is crucial for enhancing our understanding of the disease, as well as for the development of better diagnoses and treatments. Here, over half a million single-cell transcriptome data were collected from 84 OC patients across all clinical stages. Through integrative analysis, we identified heterogeneous epithelial-immune-stromal cellular compartments and their interactions in the OC microenvironment. The epithelial cells displayed clinical subtype features with functional variance. A significant increase in distinct T cell subtypes was identified including Tregs and CD8+ exhausted T cells from stage IC2. Additionally, we discovered antigen-presenting cancer-associated fibroblasts (CAFs), with myofibrob

SUBMITTER: Chai C 

PROVIDER: S-EPMC10817929 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature