Sex-Dependent Attentional Impairments in a Subchronic Ketamine Mouse Model for Schizophrenia.

ABSTRACT:

Background

The development of more effective treatments for schizophrenia targeting cognitive and negative symptoms has been limited, partly due to a disconnect between rodent models and human illness. Ketamine administration is widely used to model symptoms of schizophrenia in both humans and rodents. In mice, subchronic ketamine treatment reproduces key dopamine and glutamate dysfunction; however, it is unclear how this translates into behavioral changes reflecting positive, negative, and cognitive symptoms.

Methods

In male and female mice treated with either subchronic ketamine or saline, we assessed spontaneous and amphetamine-induced locomotor activity to measure behaviors relevant to positive symptoms, and used a touchscreen-based progressive ratio task of motivation a

SUBMITTER: Spark DL 

PROVIDER: S-EPMC10829638 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature