TPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments.

ABSTRACT: Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe₃O₄@mSiO₂ nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically a

SUBMITTER: Wang B 

PROVIDER: S-EPMC10830105 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature