Caffeic acid derivative WSY6 protects melanocytes from oxidative stress by reducing ROS production and MAPK activation.

ABSTRACT:

Purpose

Vitiligo is a chronic depigmentation disease caused by a loss of functioning melanocytes and melanin from the epidermis. Oxidative stress-induced damage to melanocytes is key in the pathogenesis of vitiligo. WSY6 is a caffeic acid derivative synthesized from epigallocatechin-3-gallate (EGCG). This study is to investigate whether the new chemical WSY6 protected melanocytes from H₂O₂-induced cell damage and to elucidate the underlying molecular mechanism.

Patients and methods

The present study compared the antioxidative potential of WSY6 with EGCG in hydrogen peroxide (H₂O₂)-treated PIG1 cells. Western blotting was used to study the protein expression of cyto-c, cleaved-caspase3, cleaved-caspase9, and the activation of MAPK f

SUBMITTER: Jin R 

PROVIDER: S-EPMC10831733 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature