Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC9496514 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Wu Jianmin J Gu Xingshi X Zhang Juan J Mi Ze Z He Zhenhu Z Dong Yuqian Y Ge Wu W Ghimire Kedar K Rong Pengfei P Wang Wei W Ma Xiaoqian X
Biomolecules 20220904 9
Pancreatic beta cells are highly susceptible to oxidative stress, which plays a crucial role in diabetes outcomes. Progress has been slow to identify molecules that could be utilized to enhance cell survival and function under oxidative stress. Itaconate, a byproduct of the tricarboxylic acid cycle, has both anti-inflammatory and antioxidant properties. The effects of itaconate on beta cells under oxidative stress are relatively unknown. We explored the effects of 4-octyl itaconate-a cell-permea ...[more]