Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC10837126 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Liu Chunxiao C Zhou Chenhao C Xia Weiya W Zhou Yifan Y Qiu Yufan Y Weng Jialei J Zhou Qiang Q Chen Wanyong W Wang Ying-Nai YN Lee Heng-Huan HH Wang Shao-Chun SC Kuang Ming M Yu Dihua D Ren Ning N Hung Mien-Chie MC
Nature communications 20240202 1
Tumor-secreted factors contribute to the development of a microenvironment that facilitates the escape of cancer cells from immunotherapy. In this study, we conduct a retrospective comparison of the proteins secreted by hepatocellular carcinoma (HCC) cells in responders and non-responders among a cohort of ten patients who received Nivolumab (anti-PD-1 antibody). Our findings indicate that non-responders have a high abundance of secreted RNase1, which is associated with a poor prognosis in vario ...[more]