The Advent of Semi-Elective Lung Transplantation-Prolonged Static Cold Storage at 10°C.

ABSTRACT: Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static cold storage (SCS) in a cooler filled with ice. Depending on the length of SCS, organs usually arrive at the recipient hospital at a temperature of 0°C-4°C. The question of the optimal storage temperature for donor lung preservation has been revisited as data from large animal experiments demonstrated that organs stored at 10°C experience less mitochondrial damage. Thus, prolonged cold ischemic times can be better tolerated at 10°C-even in pre-damaged organs. The clinical applicability of these findings was demonstrated in an international

SUBMITTER: Hoetzenecker K 

PROVIDER: S-EPMC10839059 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature