Brain metabolite levels in remitted psychotic depression with consideration of effects of antipsychotic medication.

ABSTRACT:

Background

The neurobiology of psychotic depression is not well understood and can be confounded by antipsychotics. Magnetic resonance spectroscopy (MRS) is an ideal tool to measure brain metabolites non-invasively. We cross-sectionally assessed brain metabolites in patients with remitted psychotic depression and controls. We also longitudinally assessed the effects of olanzapine versus placebo on brain metabolites.

Methods

Following remission, patients with psychotic depression were randomized to continue sertraline + olanzapine (n = 15) or switched to sertraline + placebo (n = 18), at which point they completed an MRS scan. Patients completed a second scan either 36 weeks later, relapse, or discontinuation. Where water-scaled metabolite levels were obtained and a Point-RES

SUBMITTER: Tani H 

PROVIDER: S-EPMC10844359 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature