Alleviation of monocyte exhaustion by BCG derivative mycolic acid.

ABSTRACT: Monocyte exhaustion with sustained pathogenic inflammation and immune-suppression, a hallmark of sepsis resulting from systemic infections, presents a challenge with limited therapeutic solutions. This study identified Methoxy-Mycolic Acid (M-MA), a branched mycolic acid derived from Mycobacterium bovis Bacillus Calmette-Guérin (BCG), as a potent agent in alleviating monocyte exhaustion and restoring immune homeostasis. Co-treatment of monocytes with M-MA effectively blocked the expansion of Ly6C^hi/CD38^hi/PD-L1^hi monocytes induced by LPS challenges and restored the expression of immune-enhancing CD86. M-MA treatment restored mitochondrial functions of exhausted monocytes and alleviated their suppressive activities on co-cultured T cells. Independent

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10845070 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature