Targeting the AKT-P53/CREB pathway with epicatechin for improved prognosis of traumatic brain injury.

ABSTRACT:

Aims

The aim of this study was to evaluate the effect of epicatechin, on neurological recovery and neuroinflammation after traumatic brain injury (TBI) to investigate its potential value in clinical practice.

Methods

TBI model was established in adult rats by CCI method. The effect of epicatechin was evaluated after intraperitoneal injection. Neurological recovery after TBI was assessed by Morris Water Maze, mNSS score, Rotarod test and Adhesive removal test. Protein and gene expression was assessed by Western blot, ELISA, PCR and immunofluorescence. Furthermore, the use of AKT pathway inhibitors blocked the therapeutic effects of epicatechin clarifying AKT-P53/CREB as a potential pathway for the effects of epicatechin.

Results

Administering epicatechin after TBI prev

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10848092 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature