Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice.

ABSTRACT:

Background

The existence and contribution of microglia with senescent-like alterations in the pathogenesis of age-related neurodegenerative diseases like Alzheimer's disease (AD) have been suggested in recent years. However, the identification of this distinct microglial population in vivo has proven challenging, largely due to overlaps in the inflammatory phenotype of activated and senescent microglia. Furthermore, attempts at recapitulating senescence in microglia in vitro are limited.

Objective

To identify and characterize senescent microglia that occur in vivo in an animal model of neurodegeneration driven by pathologic tau.

Methods

We analyzed the RNA expression patterns of individual microglia from normal mice and the pathogenic tau P301 S PS19 mouse model. We h

SUBMITTER: Ng PY 

PROVIDER: S-EPMC10848894 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature