Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC10853205 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Li Jingyi J Liu Xingfeng X Liu Yuanyuan Y Huang Fangmin F Liang Jiankun J Lin Yingying Y Hu Fen F Feng Jianting J Han Zeteng Z Chen Yushi Y Chen Xuan X Lin Qiaofa Q Wu Lanqin L Li Lisheng L
Cell death & disease 20240208 2
Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) is the hallmark of tumour necrosis factor α (TNF)-induced necroptosis. Here, we screened a small-molecule compound library and found that saracatinib inhibited TNF-induced necroptosis. By targeting MLKL, Sa ...[more]