Neutrophil extracellular traps linked to idiopathic pulmonary fibrosis severity and survival.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) leads to progressive loss of lung function and mortality. Understanding mechanisms and markers of lung injury in IPF is paramount to improving outcomes for these patients. Despite the lack of systemic involvement in IPF, many analyses focus on identifying circulating prognostic markers. Using a proteomic discovery method followed by ELISA validation in multiple IPF lung compartments and cohorts we explored novel markers of IPF survival.

Methods

In our discovery analysis, agnostic label-free quantitative proteomics differentiated lung tissue protein expression based on survival trajectory (n=10). Following selection of the candidate pathway (neutrophil extracellular trap (NET) formation), we subsequently validated the pres

SUBMITTER: Matson SM 

PROVIDER: S-EPMC10854325 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature