Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity.
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ABSTRACT:
SUBMITTER: Bons J
PROVIDER: S-EPMC10854995 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity.
Bons Joanna J Tadeo Ada A Scott Gary K GK Teramayi Fadzai F Tanner John J JJ Schilling Birgit B Benz Christopher C CC Ellerby Lisa M LM
Biochimica et biophysica acta. Molecular basis of disease 20230814 1
N-propargylglycine prevents 4-hydroxyproline catabolism in mouse liver and kidney. N-propargylglycine is a novel suicide inhibitor of PRODH2 and induces mitochondrial degradation of PRODH2. PRODH2 is selectively expressed in liver and kidney and contributes to primary hyperoxaluria (PH). Preclinical evaluation of N-propargylglycine efficacy as a new PH therapeutic is warranted. ...[more]
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