Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity.

ABSTRACT: The adaptive T cell response is accompanied by continuous rewiring of the T cell's electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcom

SUBMITTER: Yu H 

PROVIDER: S-EPMC10862906 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature