Reduced Bergmann glial process terminations and lateral appendages in essential tremor.

ABSTRACT:

Objective

Postmortem examination of the essential tremor cerebellum has revealed a variety of pathological changes centered in and around Purkinje cells. Studies have predominantly focused on cerebellar neuronal connections. Bergmann glial morphology has not yet been studied in essential tremor. Among their many roles, Bergmann glia in the cerebellar cortex ensheath Purkinje cell synapses and provide neuroprotection. Specifically, the complex radial processes and lateral appendages of Bergmann glia are structural domains that modulate Purkinje cell synaptic transmission. In this study, we investigate whether Bergmann glia morphology is altered in the essential tremor cerebellum.

Methods

We applied the Golgi-Kopsch method and used computerized three-dimensional cell reconstru

SUBMITTER: Ruff DS 

PROVIDER: S-EPMC10863904 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature