A cross-sectional study of MRI features and the gut microbiome in pediatric-onset multiple sclerosis.

ABSTRACT:

Objective

To identify gut microbiome features associated with MRI lesion burden in persons with pediatric-onset multiple sclerosis (symptom onset <18 years).

Methods

A cross-sectional study involving the Canadian Paediatric Demyelinating Disease Network study participants. Gut microbiome features (alpha diversity, phylum- and genus-level taxa) were derived using 16S rRNA sequencing from stool samples. T1- and T2-weighted lesion volumes were measured on brain MRI obtained within 6 months of stool sample procurement. Associations between the gut microbiota and MRI metrics (cube-root-transformed) were assessed using standard and Lasso regression models.

Results

Thirty-four participants were included; mean ages at symptom onset and MRI were 15.1 and 19.0 years, respective

SUBMITTER: Zhu F 

PROVIDER: S-EPMC10863907 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature