Resistant starches from dietary pulses improve neurocognitive health via gut-microbiome-brain axis in aged mice.

ABSTRACT:

Introduction

Cognitive decline is a common consequence of aging. Dietary patterns that lack fibers and are high in saturated fats worsen cognitive impairment by triggering pro-inflammatory pathways and metabolic dysfunctions. Emerging evidence highlights the neurocognitive benefits of fiber-rich diets and the crucial role of gut-microbiome-brain signaling. However, the mechanisms of this diet-microbiome-brain regulation remain largely unclear.

Methods

Accordingly, we herein investigated the unexplored neuroprotective mechanisms of dietary pulses-derived resistant starch (RS) in improving aging-associated neurocognitive function in an aged (60-weeks old) murine model carrying a human microbiome.

Results and discussion

Following 20-weeks dietary regimen which included a

SUBMITTER: Kadyan S 

PROVIDER: S-EPMC10864001 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature