Glutamate measurements using edited MRS.

ABSTRACT:

Purpose

To demonstrate J-difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher-Garwood-edited spectroscopy (HERMES).

Methods

Density-matrix simulations of HERMES (TE 80 ms) and 1D J-resolved (TE 31-229 ms) of glutamate (Glu), glutamine (Gln), γ-aminobutyric acid (GABA), and glutathione (GSH) were performed. HERMES comprised four sub-experiments with editing pulses applied as follows: (A) 1.9/4.56 ppm simultaneously (ON_GABA /ON_GSH ); (B) 1.9 ppm only (ON_GABA /OFF_GSH ); (C) 4.56 ppm only (OFF_GABA /ON_GSH ); and (D) 7.5 ppm (OFF_GABA /OFF_GSH ). Phantom HERMES and 1D J-resolved experiments of Glu were performed. Finally, in vivo HERMES (20-ms editing pulses) an

SUBMITTER: Saleh MG 

PROVIDER: S-EPMC10865745 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature