Dataset Information

Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.

ABSTRACT:

Context

Chronic kidney disease (CKD) is a worldwide health problem. Recent literature has shown an association of hemoglobin glycation index (HGI) and CKD in patients with dysglycemia.

Objective

The aim of this study was to reveal the impact of HGI as a predictor for incident CKD in the general population.

Methods

CKD was defined as dipstick proteinuria or estimated glomerular rate (eGFR) < 60 mL/min/1.73 m2. Impact of HGI on incident CKD was assessed using the data from CKD-free health examinees (N = 23 467, 4.1% with diabetes) followed for a mean of 5.1 years: Cox proportional hazards model was employed with multivariate adjustment for age, systolic blood pressure, eGFR, fasting plasma glucose, body mass index, log[alanine aminotransferase], log[triglycerides], high-density lipoprotein cholesterol, platelet counts, smoking, and sex. Elevated level of HGI in subjects with CKD was ascertained after propensity score matching of another group of health examinees (N = 2580, 7.6% with diabetes).

Results

In the former group, CKD developed in 2540 subjects and HGI was the second most robust predictor for CKD, following low eGFR. With adjustment for the 11 covariates, the hazard ratio of HGI (95% CI) for CKD was 1.293 (1.238 to 1.349) (P < .0001). The population attributable risk of HGI for CKD was 4.2%. In the latter group, among 708 subjects matched 1:1 for 9 covariates, HGI was significantly elevated in subjects with CKD (median [interquartile range] -0.208 [-0.504 to -0.156] vs -0.284 [-0.582 to 0.052], P = .03).

Conclusion

HGI was a novel risk factor for CKD in the general population.

SUBMITTER: Nakasone Y

PROVIDER: S-EPMC10876385 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.

Nakasone Yasuto Y Miyakoshi Takahiro T Sakuma Takahiro T Toda Shigeru S Yamada Yosuke Y Oguchi Tomomasa T Hirabayashi Kazuko K Koike Hideo H Yamashita Koh K Aizawa Toru T

The Journal of clinical endocrinology and metabolism 20240201 3

<h4>Context</h4>Chronic kidney disease (CKD) is a worldwide health problem. Recent literature has shown an association of hemoglobin glycation index (HGI) and CKD in patients with dysglycemia.<h4>Objective</h4>The aim of this study was to reveal the impact of HGI as a predictor for incident CKD in the general population.<h4>Methods</h4>CKD was defined as dipstick proteinuria or estimated glomerular rate (eGFR) < 60 mL/min/1.73 m2. Impact of HGI on incident CKD was assessed using the data from CK ...[more]

PMID: 37931239

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Project description:IntroductionA 'healthy immigrant effect' has been demonstrated for a number of chronic health conditions including cardiovascular disease, diabetes mellitus and dementia; however, the link between immigrant status and kidney health remains uncertain. We sought to compare the risk for incident chronic kidney disease (CKD) between Canadian immigrants and non-immigrants.MethodsWe conducted a population-level, observational cohort study of all adult (≥18 years of age) Ontario residents, including foreign-born immigrant Canadian citizens and non-immigrant Canadian citizens by birth, with normal baseline kidney function (outpatient estimated glomerular filtration rate (eGFR) ≥70 mL/min/1.73 m2) between 1 April 2007 and 30 September 2020 using provincial health administrative data. Multivariable Cox proportional hazard regression modelling was used to evaluate the relationship between immigrant status and the development of incident CKD (outpatient eGFR <60 mL/min/1.73m2).ResultsThe study cohort included 10 440 210 Ontario residents, consisting of 22% immigrants (n=2 253 360) and 78% (n=8 186 850) non-immigrants. The mean (SD) age and eGFR were 45 (17) years and 102 (16) mL/min/1.73 m2, respectively, and 54% of individuals were female. A total of 117 028 immigrants (5%, 7 events per 1000 person-years) and 984 277 non-immigrants (12%, 16 events per 1000 person-years) developed incident CKD during follow-up. Immigrants experienced a 20% lower risk for incident CKD compared with non-immigrants (adjusted HR 0.80, 95% CI 0.80 to 0.81). Consistent findings were seen for refugee and non-refugee immigrants, immigrants with remote (1985-2004) and recent (2005-2020) landing dates, and immigrants from different world regions. Results were similar on re-defining incident CKD as two outpatient eGFR measurements <60 mL/min/1.73 m2 at least 90 days apart, treating death as a competing risk, and adjusting for baseline albuminuria.ConclusionImmigrants experience a lower risk for incident CKD compared with non-immigrants. These findings provide evidence of a 'healthy immigrant effect' in relation to kidney health.

Dataset Information

Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.

Context

Objective

Methods

Results

Conclusion

Publications

Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.

Similar Datasets

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