Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults.

ABSTRACT:

Context

With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown.

Objective

To investigate incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism.

Design

Pooled data were used from the (1) pretrial population and (2) in-trial placebo group from 2 randomized, double-blind, placebo-controlled trials (Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism Trial and Institute for Evidence-Based Medicine in Old Age thyroid 80-plus thyroid trial).

Setting

Community-dwelling 65+ adults with subclinical hypothyroidism from the Netherlands, Switzerland, Ireland, and the United Kingdom.

SUBMITTER: van der Spoel E 

PROVIDER: S-EPMC10876405 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature