Surveillance Outcome and Genetic Findings in Individuals at High Risk of Pancreatic Cancer.

ABSTRACT:

Introduction

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate. PDAC surveillance is recommended in high-risk individuals (HRIs) with strong PDAC family history or a pathogenic germline variant (PGV) in a PDAC susceptibility gene. We aimed to explore a potential correlation between genetic status, extent of family history, pancreatic findings, and surveillance implications in heterogeneous PDAC HRIs.

Methods

A total of 239 HRIs from 202 families were tested genetically and underwent prospective pancreatic surveillance for 6 years.

Results

The cohort was divided into 3 groups: familial pancreatic cancer (FPC; 70 individuals, 54 families), familial non-FPC (81 individuals, 73 families), and hereditary pancreatic cancer (PC) (88 individuals, 75 fami

SUBMITTER: Rosner G 

PROVIDER: S-EPMC10887440 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature