Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis.

ABSTRACT:

Background

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with high mortality rates are mostly associated with acute and severe inflammation in lungs. Recently, increasing evidence supports activated inflammation and gasdermin D (GSDMD)-mediated pyroptosis in macrophage are closely associated with ALI. Basic helix-loop-helix family member e40 (Bhlhe40) is a transcription factor that is comprehensively involved in inflammation. However, there is little experimental evidence connecting Bhlhe40 and GSDMD-driven pyroptosis. The study sought to verify the hypothesis that Bhlhe40 is required for GSDMD-mediated pyroptosis in lipopolysaccharide (LPS)-induced inflammatory injury.

Method

We performe

SUBMITTER: Hu X 

PROVIDER: S-EPMC10894472 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature