Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin.

ABSTRACT:

Objective

This study is to discover hormone pathways active in early cleaving human embryos.

Methods

A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency.

Results

Over half of the 152 hormones and receptors were silent on the arrays of all cell types, and more were detected at high or moderate levels on the 8-cell arrays than on the pluripotent cell or fibroblast arrays. Eight hormone family genes were uniquely detected at least 22-fold higher on the 8-cell arrays than the stem cell arrays: AVPI1, CCK, CORT, FSTL4, GIP, GPHA2, OXT, and PPY suggesting novel roles for these proteins in early development. Ox

SUBMITTER: Harris AL 

PROVIDER: S-EPMC10894797 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature