Dataset Information

The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999-2018.

ABSTRACT:

Background

Renal impairment has been previously linked to peripheral eosinophil count (PEC), prompting an investigation into its potential relationship with chronic kidney disease (CKD). This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999-2018) to comprehensively explore the association between PEC and CKD.

Methods

Survey-weighted generalized multivariate linear regression was employed to evaluate the associations between PEC, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR), with meticulous adjustment for potential covariates. To assess non-linear correlations, a restricted cubic spline analysis was conducted. Sensitivity analysis was performed to test the stability of results.

Results

The study included a total of 9224 participants with non-dialysis CKD. In the multivariate linear regression model, after comprehensive adjustment for potential covariates, PEC showed a negative association with eGFR (β per 100 cells/uL increase in PEC, -0.71; 95% CI, -1.04, -0.37), while demonstrating a positive trend with UACR (β per 100 cells/uL increase in PEC, 10.21; 95% CI, 1.37, 19.06). The restrictive cubic spline curve analysis suggested that these associations occurred within the range of 0 to 400 cells/uL for PEC. Sensitivity analysis supported the stability of the observed results.

Conclusions

Circulating eosinophil levels are negatively correlated with eGFR and demonstrate a positive trend with UACR, when PEC falls within the range of less than 400 cells/uL among adults with CKD. Further research is warranted to validate these findings.

SUBMITTER: Han S

PROVIDER: S-EPMC10896169 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature

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Publications

The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999-2018.

Han Shisheng S Jia Meng M Yuan Wenli W Wang Yi Y Lu Yan Y Xu Yanqiu Y Shang Li L

Renal failure 20240223 1

<h4>Background</h4>Renal impairment has been previously linked to peripheral eosinophil count (PEC), prompting an investigation into its potential relationship with chronic kidney disease (CKD). This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES 1999-2018) to comprehensively explore the association between PEC and CKD.<h4>Methods</h4>Survey-weighted generalized multivariate linear regression was employed to evaluate the associations between ...[more]

PMID: 38390735

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Dataset Information

The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999-2018.

Background

Methods

Results

Conclusions

Publications

The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999-2018.

Similar Datasets

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