Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition.

ABSTRACT: Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained from the fermentation products of Arthrinium arundinis separated from the gut of a centipede collected in our Tongji campus, showed a remarkable neuroprotective effect. Further investigation was conducted to clarify the specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis in SH-SY5Y cells. Network pharmacology analysis predicted that the targets of LC were most likely directly related to oxidative stress and the regulation of inflammatory factor-associated sig

SUBMITTER: Cao J 

PROVIDER: S-EPMC10897105 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature