Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice.

ABSTRACT:

Introduction

In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which coordinates the circadian rhythm and controls locomotor activity rhythms. In addition to SCN cells, the peripheral tissues and embryonic fibroblasts also have clock genes, such as Per1/2 and Bmal1, which generate the transcriptional-translational feedback loop to produce an approximately 24-h cycle. Aging adversely affects the circadian clock system and locomotor functions. Oak extract has been reported to improve age-related physiological changes. However, no study has examined the effect of oak extract on the circadian clock system.

Methods

We examined the effects of oak extract and its metabolites (urolithin A [ULT] and ellagic acid

SUBMITTER: Haraguchi A 

PROVIDER: S-EPMC10899999 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature