Factors Affecting Recurrence and Survival for Patients with High-Risk Stage II Melanoma.

ABSTRACT:

Background

In the current era of effective adjuvant therapies and de-escalation of surgery, distinguishing which patients with high-risk stage II melanoma are at increased risk of recurrence after excision of the primary lesion is essential to determining appropriate treatment and surveillance plans.

Methods

A single-center retrospective study analyzed patients with stage IIB or IIC melanoma. Demographic and tumor data were collected, and genomic analysis of formalin-fixed, paraffin-embedded tissue samples was performed via an internal next-generation sequencing (NGS) platform (SNaPshot). The end points examined were relapse-free survival (RFS), distant metastasis-free survival (DMFS), overall survival (OS), and melanoma-specific survival (MSS). Uni- and multivariable Cox re

SUBMITTER: Dedeilia A 

PROVIDER: S-EPMC10908640 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature