Efficacy of a low dose of antivenom for severe neuroparalysis in <i>Bungarus caeruleus</i> (common krait) envenomation: a pilot study.

ABSTRACT:

Introduction

Despite the widespread use of antivenom for the treatment of snakebite envenoming in the Indian subcontinent, the ideal dose of antivenom has been a point of contention. Low-dose regimens can economize on a scarce resource in low- and middle-income countries. This study assessed the effectiveness of a low-dose (10 vials) antivenom regimen compared to the usual 20 vials in patients with krait bite neuroparalysis requiring mechanical ventilation.

Methods

This study was a prospective controlled pilot study conducted in a tertiary-care hospital in north India. Participants were eligible if they were ≥12 years old, had krait bite neurotoxicity, showed severe paralysis requiring mechanical ventilation, and had access to antivenom therapy within 24 h of the bite. The p

SUBMITTER: Pannu AK 

PROVIDER: S-EPMC10913380 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature