Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice.

ABSTRACT: In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting African children, increases susceptibility to disseminated non-typhoidal Salmonella disease in mice and impairs terminal neutrophil maturation. Immature neutrophils had reduced expression of Slc11a1, a gene that encodes a metal ion transporter generally thought to restrict pathogen growth in macrophages. Adoptive transfer of SLC11A1-proficient neutrophils, but not SLC11A1-deficient neutrophils, reduced systemic Salmonella burden in Slc11a1^-/- mice or mice with vitamin A defi

SUBMITTER: Lokken-Toyli KL 

PROVIDER: S-EPMC10914596 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature