Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease.

ABSTRACT:

Introduction

The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood.

Methods

To address this problem, we investigated cellular metabolism and immune responses ("immunometabolism endophenotype") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort.

Results

We identified sex-specific metabolites, immune and metabolic genes, and pathways associated with the AD diagnosis an

SUBMITTER: Hou Y 

PROVIDER: S-EPMC10916937 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature