Feasibility of tracking invasive Escherichia coli disease among older adults in a community setting: A prospective observational study.

ABSTRACT:

Purpose

Invasive Escherichia coli disease (IED) encompasses a diverse range of sterile site infections. This study evaluated the feasibility of capturing IED among community-dwelling older adults to inform the implementation of a phase 3 efficacy trial of a novel vaccine against IED (NCT04899336).

Methods

EXPECT-1 (NCT04087681) was a prospective, multinational, observational study conducted in medically stable participants aged ≥ 60 years. At least 50% of participants were selected based on a history of urinary tract infection (UTI) in the previous 10 years. The main outcomes were the incidence of IED and the number of hospitalisations reported by the site vs participant. The length of follow-up was 12 months. In a US-based substudy, a smartphone-based geofencing was evaluat

SUBMITTER: Doua J 

PROVIDER: S-EPMC10917840 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature