Migratory pattern of zoonotic Toxocara cati and T. canis in experimentally infected pigs.

ABSTRACT:

Background

Over a billion people are infected with Toxocara canis or T. cati, the roundworms of dogs and cats. Historically, T. canis has been considered the main species responsible for human toxocarosis, but as serodiagnosis cannot discriminate between the two species, this remains unresolved. We used pigs as a relevant large animal model for human infection to assess the migratory pattern of T. cati and T. canis.

Methods

Pigs were inoculated with T. cati or T. canis eggs or PBS (negative controls) and necropsied 14 or 31 days later. Different organs and tissues were examined for parasites and pathological changes.

Results

Overall, the two parasite species had a similar migration pattern reaching multiple organs and tissues, including the mesenteric lymph nodes, liv

SUBMITTER: Poulsen CS 

PROVIDER: S-EPMC10917876 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature