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Utility of 2-Chloro-N-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines].

ABSTRACT: A series of novel thieno[2,3-b]pyridines linked to N-aryl carboxamides or (carbonylphenoxy)-N-(aryl)acetamides, as well as bis(thieno[2,3-b]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compounds.

SUBMITTER: Salem ME 

PROVIDER: S-EPMC10918660 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Utility of 2-Chloro-<i>N</i>-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines].

Salem Mostafa E ME   Abdullah Abbas H AH   Zaki Magdi E A MEA   Abdelhamid Ismail A IA   Elwahy Ahmed H M AHM  

ACS omega 20240221 9

A series of novel thieno[2,3-<i>b</i>]pyridines linked to <i>N</i>-aryl carboxamides or (carbonylphenoxy)-<i>N</i>-(aryl)acetamides, as well as bis(thieno[2,3-<i>b</i>]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compoun  ...[more]

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