Effects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial.

ABSTRACT:

Background

A significant reduction in regional cerebral oxygen saturation (rSO₂) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO₂, pulmonary oxygenation, and hemodynamics during OLV.

Methods

Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH₂O, 5 cmH₂O, and 10 cmH₂O. The primary endpoint was rSO₂ in patients receiving OLV 20 min after adjusting the PEEP. The secondary outcomes included hemodynamic and respiratory variables.

Results

After ex

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10919006 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature