Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4⁺ T-Cells by Decreasing Viral Release.

ABSTRACT: The mechanistic target of rapamycin (mTOR) positively regulates multiple steps of the HIV-1 replication cycle. We previously reported that a 12-weeks supplementation of antiretroviral therapy (ART) with metformin, an indirect mTOR inhibitor used in type-2 diabetes treatment, reduced mTOR activation and HIV transcription in colon-infiltrating CD4⁺ T-cells, together with systemic inflammation in nondiabetic people with HIV-1 (PWH). Herein, we investigated the antiviral mechanisms of metformin. In a viral outgrowth assay performed with CD4⁺ T-cells from ART-treated PWH, and upon infection in vitro with replication-competent and VSV-G-pseudotyped HIV-1, metformin decreased virion release, but increased the frequency of productively infected CD4^lowHIV-p24

SUBMITTER: Fert A 

PROVIDER: S-EPMC10925111 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature