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Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.

ABSTRACT: In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.

SUBMITTER: El Mahdaoui A 

PROVIDER: S-EPMC10935173 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.

El Mahdaoui Amal A   Radi Smaail S   Draoui Youssef Y   El Massaoudi Mohamed M   Ouahhoud Sabir S   Asehraou Abdeslam A   Bentouhami Nour Eddine NE   Saalaoui Ennouamane E   Benabbes Redouane R   Robeyns Koen K   Garcia Yann Y  

Molecules (Basel, Switzerland) 20240306 5

In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub>2</sub></b>), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(<b>L<sub>1</sub></b>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>C<sub>1</sub></b>) and a dinuclear complex [Cd<sub>2</sub>(<  ...[more]

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