Dataset Information

Genetic Insights into Glycine's Protective Role Against CAD - European and East Asia, 2015 and 2020.

ABSTRACT:

Introduction

The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease (CAD) using a two-step Mendelian randomization (MR) analysis.

Methods

We analyzed data from genome-wide association studies (GWAS) conducted on European and East Asian populations. To assess the causal effects of circulating glycine levels on the risk of CAD. We used the inverse-variance weighting (IVW), weighted median (WM), MR-Egger, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods. Furthermore, we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.

Results

The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans [odds ratio ( OR)=0.84, 95% confidence interval ( CI): 0.72, -0.98; P=0.029] and East Asians: ( OR=0.76, 95% CI: 0.66, -0.89; P=3.57×10 ^-4). Sensitivity analysis confirmed the robustness of these findings. Additionally, our results suggest that about 6.06% of the observed causal effect is mediated through genetically predicted systolic blood pressure (SBP) in the European population.

Discussion

Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD, and provide valuable methodological insights for the prevention and treatment of this condition.

SUBMITTER: Yu J

PROVIDER: S-EPMC10937183 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Genetic Insights into Glycine's Protective Role Against CAD - European and East Asia, 2015 and 2020.

Yu Jiaying J Zhu Zhuolin Z Wang Ting T Wei Yuanhao Y Huang Lianjie L Zhang Qianru Q Zhang Yuting Y Wang Yiran Y Liu Guiyou G Shu Xiang X Feng Rennan R

China CDC weekly 20240301 9

<h4>Introduction</h4>The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease (CAD) using a two-step Mendelian randomization (MR) analysis.<h4>Methods</h4>We analyzed data from genome-wide association studies (GWAS) conducted on European and East Asian populations. To assess the causal effects of circulating glycine levels on the risk of CAD. We used the inverse-variance weighting (IVW), weighted median (WM), MR-E ...[more]

PMID: 38495593

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Dataset Information

Genetic Insights into Glycine's Protective Role Against CAD - European and East Asia, 2015 and 2020.

Introduction

Methods

Results

Discussion

Publications

Genetic Insights into Glycine's Protective Role Against CAD - European and East Asia, 2015 and 2020.

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